Summary

Name ADCY7
Full Name Adenylate cyclase type 7
Synonyms ATP pyrophosphate-lyase 7, Adenylate cyclase type VII, Adenylyl cyclase 7 | KIAA0037
Primary ID P51828
Links - -
Type protein
Relations 2
Function Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (By similarity). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates quantity img/direct-activation.png chemical modification 3',5'-cyclic AMP 0.8
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/indirect-activation.png ADCY7 0.292
Publications: 1 Organism: Homo Sapiens