Summary

Name ITGA8
Full Name Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]
Synonyms ITA8_HUMAN |
Primary ID P53708
Links - -
Type protein
Relations 1
Function Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding A8/b1 integrin 0.811
Publications: 1