| Name
|
 SLURP1
|
| Full Name |
Secreted Ly-6/uPAR-related protein 1 |
| Synonyms |
SLURP-1, ARS component B, ARS(component B)-81/S, Anti-neoplastic urinary protein, ANUP | ARS |
| Primary ID |
P55000 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Has an antitumor activity (PubMed:8742060). Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884). In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431). In T cells may be involved in regulation of intracellular Ca(2+) signaling (PubMed:17286989). Seems to have an immunomodulatory function in the cornea (By similarity). The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU-dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896). |
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