Relation Results

Summary

Name SEC13
Full Name Protein SEC13 homolog
Synonyms GATOR complex protein SEC13, SEC13-like protein 1, SEC13-related protein | D3S1231E, SEC13L1, SEC13R
Primary ID P55735
Links - -
Type protein
Relations 3
Function Functions as a component of the nuclear pore complex (NPC) and the COPII coat. At the endoplasmic reticulum, SEC13 is involved in the biogenesis of CO ...
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Type: Score: Layout: SPV 
0.8620.8460.581SEC13GATOR2COPII vesicleNPC

Relations

Regulator
Mechanism
target
score
+ form complex img/form-complex.png binding GATOR2 0.862
Identifier Residue Sequence Organism Cell Line
SIGNOR-255305 Homo sapiens
pmid sentence
Here, we identify GATOR as a complex that interacts with the Rags and is composed of two subcomplexes we call GATOR1 and 2. Inhibition of GATOR1 subunits (DEPDC5, Nprl2, and Nprl3) makes mTORC1 signaling resistant to amino acid deprivation. In contrast, inhibition of GATOR2 subunits (Mios, WDR24, WDR59, Seh1L, Sec13) suppresses mTORC1 signaling and epistasis analysis shows that GATOR2 negatively regulates DEPDC5
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding COPII vesicle 0.846
Identifier Residue Sequence Organism Cell Line
SIGNOR-265296 Homo sapiens
pmid sentence
The Core Components of COPII Vesicles from HeLa Cells|Membrane-bound Sar1 then recruits the inner COPII coat subcomplex, the Sec23/24 heterodimer. Subsequently, together with cargo proteins recruited by the Sec24 subunit, Sar1 and Sec23/24 assemble into so-called pre-budding complexes. Finally, outer coat subcomplexes, comprising heterotetrameric Sec13/31 complexes, are recruited onto pre-budding complexes to complete the two-layered COPII coat
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding NPC 0.581
Identifier Residue Sequence Organism Cell Line
SIGNOR-262091
pmid sentence
The protein inventory of the NPC has been studied for a very diverse set of eukaryotes, including trypanosomes, fungi, plants, animals, and humans [4], [5], [6], [7], [8], [9]. In all cases, about 30 different Nups were found (Fig. 2).
Publications: 1
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