| Name
|
 PRDM15
|
| Full Name |
PR domain zinc finger protein 15 |
| Synonyms |
PR domain-containing protein 15, Zinc finger protein 298 | C21orf83, ZNF298 |
| Primary ID |
P57071 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Sequence-specific DNA-binding transcriptional regulator. Plays a role as a molecular node in a transcriptional network regulating embryonic development and cell fate decision. Stimulates the expression of upstream key transcriptional activators and repressors of the Wnt/beta-catenin and MAPK/ERK pathways, respectively, that are essential for naive pluripotency and self-renewal maintenance of embryonic stem cells (ESCs). Specifically promotes SPRY1 and RSPO1 transcription activation through recognition and direct binding of a specific DNA sequence in their promoter regions. Involved in early embryo development (By similarity). Plays also a role in induced pluripotent stem cells (iPSCs) reprogramming (PubMed:28740264). |
4.0