3.0
Summary
| Name |  UBE2M
|
| Full Name | NEDD8-conjugating enzyme Ubc12 |
| Synonyms | NEDD8 carrier protein, Ubiquitin-conjugating enzyme E2 M | UBC12 |
| Primary ID | P61081 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX1, but not RBX2, suggests that the RBX1-UBE2M complex neddylates specific target proteins, such as CUL1, CUL2, CUL3 and CUL4. Involved in cell proliferation. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | Ub:E1 (UBA1 substrate) | up-regulates activity 
ubiquitination
|
UBE2M | 0.716 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | Ub:E1 (UBA6 substrate) | up-regulates activity
ubiquitination
|
UBE2M | 0.689 |
| Publications: | 1 | Organism: | Homo Sapiens | |