Summary

Name UBE2K
Full Name Ubiquitin-conjugating enzyme E2 K
Synonyms E2 ubiquitin-conjugating enzyme K, Huntingtin-interacting protein 2, HIP-2, Ubiquitin carrier protein, Ubiquitin-conjugating enzyme E2-25 kDa, Ubiquitin-conjugating enzyme E2(25K), Ubiquitin-conjugating enzyme E2-25K, Ubiquitin-protein ligase | HIP2, LIG
Primary ID P61086
Links - -
Type protein
Relations 3
Function Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro, in the presence or in the absence of BRCA1-BARD1 E3 ubiquitin-protein ligase complex, catalyzes the synthesis of 'Lys-48'-linked polyubiquitin chains. Does not transfer ubiquitin directly to but elongates monoubiquitinated substrate protein. Mediates the selective degradation of short-lived and abnormal proteins, such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. Ubiquitinates huntingtin. May mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53/TP53. Proposed to be involved in ubiquitination and proteolytic processing of NF-kappa-B; in vitro supports ubiquitination of NFKB1. In case of infection by cytomegaloviruses may be involved in the US11-dependent degradation of MHC class I heavy chains following their export from the ER to the cytosol. In case of viral infections may be involved in the HPV E7 protein-dependent degradation of RB1.

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Relations

Regulator Mechanism target score ℹ
+ Ub:E1 (UBA1 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2K 0.839
Publications: 1 Organism: Homo Sapiens
+ Ub:E1 (UBA6 substrate)up-regulates activity img/direct-activation.png ubiquitination UBE2K 0.749
Publications: 1 Organism: Homo Sapiens
+ UBE2Kup-regulates activity img/direct-activation.png binding RNF138 0.515
Publications: 1 Organism: Homo Sapiens