Summary

Name HAND2
Full Name Heart- and neural crest derivatives-expressed protein 2
Synonyms Class A basic helix-loop-helix protein 26, bHLHa26, Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2, dHAND | BHLHA26, DHAND
Primary ID P61296
Links - -
Type protein
Relations 1
Function Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png binding HAND2 0.2
Publications: 1 Organism: In Vitro