Summary

Name SNRPE
Full Name Small nuclear ribonucleoprotein E
Synonyms snRNP-E, Sm protein E, Sm-E, SmE |
Primary ID P62304
Links - -
Type protein
Relations 3
Function Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (PubMed:11991638, PubMed:18984161, PubMed:23246290, PubMed:19325628, PubMed:23333303, PubMed:25555158, PubMed:26912367, PubMed:28502770, PubMed:28781166, PubMed:28076346). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (PubMed:11991638, PubMed:28502770, PubMed:28781166, PubMed:28076346). Is also a component of the minor U12 spliceosome (PubMed:15146077). As part of the U7 snRNP it is involved in histone 3'-end processing (PubMed:12975319). May indirectly play a role in hair development (PubMed:23246290).

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding U1 snRNP complex 0.939
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding U4/U6.U5 snRNP complex 0.824
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding U2 snRNP complex 0.716
Publications: 1 Organism: Homo Sapiens