Summary

Name PHC1
Full Name Polyhomeotic-like protein 1
Synonyms hPH1, Early development regulatory protein 1 | EDR1, PH1
Primary ID P78364
Links - -
Type protein
Relations 1
Function Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility. Required for proper control of cellular levels of GMNN expression.

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Relations

Regulator Mechanism target score ℹ
+ PHC1form complex img/form-complex.png binding Polycomb repressive complex 1 0.81
Publications: 1 Organism: Homo Sapiens