+ |
estramustine | down-regulates activity
chemical inhibition
|
MAP1A |
0.8 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-259297 |
|
|
Homo sapiens |
DU-145 Cell |
pmid |
sentence |
1647395 |
Estramustine is a novel anti-microtubule drug shown to bind MAP-1 and MAP-2 (microtubule-associated proteins) in vitro. In this paper we have shown that estramustine specifically binds MAP-1A in Du 145a cells, resulting in disruption of MAP-1A microtubules and inhibition of type IV collagenase secretion. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
DYRK1A | up-regulates activity
phosphorylation
|
MAP1A |
0.2 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-279032 |
|
|
Homo sapiens |
|
pmid |
sentence |
22514676 |
The phosphorylation of MAP1A and MAP2 by Dyrk1A was further confirmed by immunoprecipitating these proteins from the soluble fraction obtained after phosphorylating MTs (XREF_FIG). |
|
Publications: |
1 |
Organism: |
Homo Sapiens |