3.0
Summary
| Name |  CRADD
|
| Full Name | Death domain-containing protein CRADD |
| Synonyms | Caspase and RIP adapter with death domain, RIP-associated protein with a death domain | RAIDD |
| Primary ID | P78560 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis (PubMed:9044836, PubMed:15073321, PubMed:16652156, PubMed:17159900, PubMed:17289572). Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway (PubMed:8985253). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CRADD | form complex 
binding
|
Caspase-2 PIDDosome | 0.921 |
| Publications: | 1 | Organism: | Homo Sapiens | |