| + |
MYLIP | down-regulates quantity by destabilization 
ubiquitination
|
VLDLR |
0.685 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-271487 |
|
|
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 20427281 |
Here we demonstrate that Idol also targets two closely related LDLR family members, VLDLR and ApoE receptor 2 (ApoER2), proteins implicated in both neuronal development and lipid metabolism. Idol triggers ubiquitination of the VLDLR and ApoER2 on their cytoplasmic tails, leading to their degradation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
HIC1 | down-regulates quantity by repression 
transcriptional regulation
|
VLDLR |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-254244 |
|
|
Homo sapiens |
U2-OS Cell, MDA-MB-231 Cell |
| pmid |
sentence |
| 24076391 |
The Reelin receptors ApoER2 and VLDLR are direct target genes of HIC1. ectopic expression of HIC1 in U2OS and MDA-MB-231 cell lines decreases expression of the ApoER2 and VLDLR genes, encoding two canonical tyrosine kinase receptors for Reelin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
TFPI | up-regulates 
binding
|
VLDLR |
0.262 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106353 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278667 |
Binding studies revealed that full-length tfpi, but not the truncated tfpi molecule, is recognized by the very low density lipoprotein receptor (vldl receptor) indicating that this receptor is a novel high affinity endothelial cell receptor for tfpi |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
RELN | up-regulates
binding
|
VLDLR |
0.785 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106295 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278667 |
The hypothesis that the vldl receptor signals in response to reelin binding was recently supported by studies (37) showing direct binding of reelin to the vldl receptor and changes in tyrosine phosphorylation in response to reelin-vldl receptor association. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
APOE | up-regulates
binding
|
VLDLR |
0.637 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-106221 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 11278667 |
Several ligands for the vldl receptor have been identified in addition to tfpi. These include apolipoprotein e (apoe) |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
VLDLR
- 
- 