4.0
Summary
| Name |  OGDH
|
| Full Name | 2-oxoglutarate dehydrogenase, mitochondrial |
| Synonyms | 2-oxoglutarate dehydrogenase complex component E1, OGDC-E1, Alpha-ketoglutarate dehydrogenase | |
| Primary ID | Q02218 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | 2-oxoglutarate dehydrogenase (E1) component of the 2-oxoglutarate dehydrogenase complex (OGDHC), which mediates the decarboxylation of alpha-ketoglutarate (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and CO(2) (PubMed:24495017). The 2-oxoglutarate dehydrogenase complex is mainly active in the mitochondrion (PubMed:29211711). A fraction of the 2-oxoglutarate dehydrogenase complex also localizes in the nucleus and is required for lysine succinylation of histones: associates with KAT2A on chromatin and provides succinyl-CoA to histone succinyltransferase KAT2A (PubMed:29211711). |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | OGDH | form complex 
binding
|
OGDC | 0.743 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| Pathways: | Citric acid cycle - Krebs cycle | |||