Relation Results

Summary

Name PTH1R
Full Name Parathyroid hormone/parathyroid hormone-related peptide receptor
Synonyms PTH/PTHrP type I receptor, PTH/PTHr receptor, Parathyroid hormone 1 receptor, PTH1 receptor | PTHR, PTHR1
Primary ID Q03431
Links - -
Type protein
Relations 12
Function Receptor for parathyroid hormone and for parathyroid hormone-related peptide. The activity of this receptor is mediated by G proteins which activate a ...
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Type: Score: Layout: SPV 
0.5030.80.2770.7610.310.290.3130.340.3850.3040.7720.346PTH1RGNASParathyroid hormone-related peptide (1-36)GNAQPTHLHSLC34A1CYP24A1DKK1LRP6SOSTCYP27B1PTHSLC34A3

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Relations
Regulator
Mechanism
target
score ℹ
+ PTH1Rup-regulates activity img/direct-activation.png binding GNAS 0.503
Identifier Residue Sequence Organism Cell Line
SIGNOR-270551
pmid sentence
This calciotropic hormone exerts its actions via binding to the PTH/PTH-related peptide receptor (PTH1R), which couples to multiple heterotrimeric G proteins, including Gs and Gq/11.
Publications: 1
+ Parathyroid hormone-related peptide (1-36)up-regulates activity img/direct-activation.png chemical activation PTH1R 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-257575 Homo sapiens HEK-293A Cell
pmid sentence
Here we systematically quantified ligand-induced interactions between 148 GPCRs and all 11 unique G alpha subunit C-termini. For each receptor, we probed chimeric G alpha subunit activation via a transforming growth factor-alpha (TGF alpha) shedding response in HEK293 cells lacking endogenous Gq/11- and G12/13- signaling. | We defined positive coupling if any member of the subfamily scored LogRAi ≥ -1 and negative coupling if all of the members scored LogRAi < -1 (Figure 3A-B). ROC analysis gives AUC = 0.78 (Figure S4A) when considering high-confidence known coupling data and suggested a threshold of LogRAi ≥ -1.0 for defining true couplings. | The score associated to this interaction has a LogRAi ≥ -1.0.
Publications: 1 Organism: Homo Sapiens
+ PTH1Rup-regulates activity img/direct-activation.png binding GNAQ 0.277
Identifier Residue Sequence Organism Cell Line
SIGNOR-270550
pmid sentence
This calciotropic hormone exerts its actions via binding to the PTH/PTH-related peptide receptor (PTH1R), which couples to multiple heterotrimeric G proteins, including Gs and Gq/11.
Publications: 1
+ PTHLHup-regulates activity img/direct-activation.png binding PTH1R 0.761
Identifier Residue Sequence Organism Cell Line
SIGNOR-270549 in vitro
pmid sentence
Prostate-specific antigen was found to specifically cleave PTHrP 1-141 in a time- and dose-dependent manner.|The preferred PSA cleavage site of PTHrP 1-141 was determined to be at the carboxyl-terminus of phenylalanine 23, consistent with chymotryptic-like enzymatic activity of PSA. Cleavage of PTHrP by PSA completely abolished the ability of PTHrP to stimulate cAMP production.
Publications: 1 Organism: In Vitro
+ PTH1Rdown-regulates quantity img/indirect_inhibition.png SLC34A1 0.31
Identifier Residue Sequence Organism Cell Line
SIGNOR-270556
pmid sentence
PTH inhibits reabsorption of phosphate from the glomerular filtrate in RPT by decreasing the abundance of sodium-phosphate co-transporters NPT2a and NPT2c on the apical membrane, thus enhancing renal phosphate excretion
Publications: 1
+ PTH1Rup-regulates quantity img/indirect-activation.png CYP24A1 0.29
Identifier Residue Sequence Organism Cell Line
SIGNOR-270555
pmid sentence
These PTH actions are mainly mediated by Gsalpha signaling, which induces the expression of the gene encoding 25-hydroxyvitamin D 1alpha-hydroxylase (Cyp27b1) and destabilizes the transcript encoding vitamin D 24-hydroxylase (Cyp24a1)
Publications: 1
+ PTH1Rdown-regulates quantity img/indirect_inhibition.png DKK1 0.313
Identifier Residue Sequence Organism Cell Line
SIGNOR-270553
pmid sentence
Furthermore, PTH acts on osteocytes to suppress the expression of sclerostin, an inhibitor of canonical Wnt signaling (Li, et al. 2005; Semenov, et al. 2005)). PTH action on sclerostin is primarily through cAMP signaling (Keller and Kneissel 2005) and mediated by Myocyte enhancer factor-2 (MEF2) transcriptional regulators (Leupin, et al. 2007). Using the cAMP signaling pathway in osteoblasts, PTH also inhibits the expression of Dickkopf 1 (Dkk1) (Guo et al. 2010a), which is another Wnt pathway inhibitor 
Publications: 1
+ PTH1Rup-regulates img/direct-activation.png binding LRP6 0.34
Identifier Residue Sequence Organism Cell Line
SIGNOR-199533 Homo sapiens
pmid sentence
Parathyroid hormone (pth) binding to its receptor pth1r induces association of the pthpth1r complex with lrp6and phosphorylation of pppsp sites by protein kinase_ a, which in turn triggers wnt.
Publications: 1 Organism: Homo Sapiens
+ PTH1Rdown-regulates quantity img/indirect_inhibition.png SOST 0.385
Identifier Residue Sequence Organism Cell Line
SIGNOR-270552
pmid sentence
Furthermore, PTH acts on osteocytes to suppress the expression of sclerostin, an inhibitor of canonical Wnt signaling (Li, et al. 2005; Semenov, et al. 2005)). PTH action on sclerostin is primarily through cAMP signaling (Keller and Kneissel 2005) and mediated by Myocyte enhancer factor-2 (MEF2) transcriptional regulators (Leupin, et al. 2007). Using the cAMP signaling pathway in osteoblasts, PTH also inhibits the expression of Dickkopf 1 (Dkk1) (Guo et al. 2010a), which is another Wnt pathway inhibitor 
Publications: 1
+ PTH1Rup-regulates quantity img/indirect-activation.png CYP27B1 0.304
Identifier Residue Sequence Organism Cell Line
SIGNOR-270554
pmid sentence
These PTH actions are mainly mediated by Gsalpha signaling, which induces the expression of the gene encoding 25-hydroxyvitamin D 1alpha-hydroxylase (Cyp27b1) and destabilizes the transcript encoding vitamin D 24-hydroxylase (Cyp24a1)
Publications: 1
+ PTHup-regulates img/direct-activation.png binding PTH1R 0.772
Identifier Residue Sequence Organism Cell Line
SIGNOR-182039 Homo sapiens
pmid sentence
Here we show that binding of pth to its receptor pth1r induced association of lrp6, a coreceptor of wnt, with pth1r. The formation of the ternary complex containing pth, pth1r, and lrp6 promoted rapid phosphorylation of lrp6, which resulted in the recruitment of axin to lrp6, and stabilization of beta-catenin.
Publications: 1 Organism: Homo Sapiens
+ PTH1Rdown-regulates quantity img/indirect_inhibition.png SLC34A3 0.346
Identifier Residue Sequence Organism Cell Line
SIGNOR-270557
pmid sentence
PTH inhibits reabsorption of phosphate from the glomerular filtrate in RPT by decreasing the abundance of sodium-phosphate co-transporters NPT2a and NPT2c on the apical membrane, thus enhancing renal phosphate excretion
Publications: 1
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