| Name
|
 TGM3
|
| Full Name |
Protein-glutamine gamma-glutamyltransferase E |
| Synonyms |
Transglutaminase E, TG(E), TGE, TGase E, Transglutaminase-3, TGase-3 | |
| Primary ID |
Q08188 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Catalyzes the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in various proteins, as well as the conjugation of polyamines to proteins. Involved in the formation of the cornified envelope (CE), a specialized component consisting of covalent cross-links of proteins beneath the plasma membrane of terminally differentiated keratinocytes. Catalyzes small proline-rich proteins (SPRR1 and SPRR2) and LOR cross-linking to form small interchain oligomers, which are further cross-linked by TGM1 onto the growing CE scaffold (By similarity). In hair follicles, involved in cross-linking structural proteins to hardening the inner root sheath. |
4.0