Summary

Name CD47
Full Name Leukocyte surface antigen CD47
Synonyms Antigenic surface determinant protein OA3, Integrin-associated protein, IAP, Protein MER6 | MER6
Primary ID Q08722
Links - -
Type protein
Relations 2
Function Has a role in both cell adhesion by acting as an adhesion receptor for THBS1 on platelets, and in the modulation of integrins. Plays an important role in memory formation and synaptic plasticity in the hippocampus (By similarity). Receptor for SIRPA, binding to which prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells. Interaction with SIRPG mediates cell-cell adhesion, enhances superantigen-dependent T-cell-mediated proliferation and costimulates T-cell activation. May play a role in membrane transport and/or integrin dependent signal transduction. May prevent premature elimination of red blood cells. May be involved in membrane permeability changes induced following virus infection.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding Ankyrin complex 0.379
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding CD47 0.581
Publications: 1 Organism: Homo Sapiens