| Name
|
 ACSM1
|
| Full Name |
Acyl-coenzyme A synthetase ACSM1, mitochondrial |
| Synonyms |
Acyl-CoA synthetase medium-chain family member 1, Butyrate--CoA ligase 1, Butyryl-coenzyme A synthetase 1, Lipoate-activating enzyme, Middle-chain acyl-CoA synthetase 1 | BUCS1, LAE, MACS1 |
| Primary ID |
Q08AH1 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Catalyzes the activation of fatty acids by CoA to produce an acyl-CoA, the first step in fatty acid metabolism (PubMed:10434065). Capable of activating medium-chain fatty acids (e.g. butyric (C4) to decanoic (C10) acids), and certain carboxylate-containing xenobiotics, e.g. benzoate (PubMed:10434065). Also catalyzes the activation of lipoate to lipoyl-nucleoside monophosphate (By similarity). Activates lipoate with GTP at a 1000-fold higher rate than with ATP and activates both (R)- and (S)-lipoate to the respective lipoyl-GMP, with a preference for (R)-lipoate (By similarity). |
4.0