| + |
PTPN13 | down-regulates 
dephosphorylation
|
INSR |
0.263 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132551 |
Tyr1185 |
FGMTRDIyETDYYRK |
Homo sapiens |
|
| pmid |
sentence |
| 15611135 |
We demonstrate that ptpl1, like ptp1b, interacts with and dephosphorylates a bis-phosphorylated insulin receptor peptide more efficiently than monophosphorylated peptides, indicating that ptpl1 may down-regulate the phosphatidylinositol 3-kinase pathway, by dephosphorylating insulin or growth factor receptors that contain tandem phosphotyrosines. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132555 |
Tyr1189 |
RDIYETDyYRKGGKG |
Homo sapiens |
|
| pmid |
sentence |
| 15611135 |
We demonstrate that ptpl1, like ptp1b, interacts with and dephosphorylates a bis-phosphorylated insulin receptor peptide more efficiently than monophosphorylated peptides, indicating that ptpl1 may down-regulate the phosphatidylinositol 3-kinase pathway, by dephosphorylating insulin or growth factor receptors that contain tandem phosphotyrosines. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132559 |
Tyr1190 |
DIYETDYyRKGGKGL |
Homo sapiens |
|
| pmid |
sentence |
| 15611135 |
We demonstrate that ptpl1, like ptp1b, interacts with and dephosphorylates a bis-phosphorylated insulin receptor peptide more efficiently than monophosphorylated peptides, indicating that ptpl1 may down-regulate the phosphatidylinositol 3-kinase pathway, by dephosphorylating insulin or growth factor receptors that contain tandem phosphotyrosines. |
|
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-132563 |
Tyr999 |
YASSNPEyLSASDVF |
Homo sapiens |
|
| pmid |
sentence |
| 15611135 |
We demonstrate that ptpl1, like ptp1b, interacts with and dephosphorylates a bis-phosphorylated insulin receptor peptide more efficiently than monophosphorylated peptides, indicating that ptpl1 may down-regulate the phosphatidylinositol 3-kinase pathway, by dephosphorylating insulin or growth factor receptors that contain tandem phosphotyrosines. |
|
| Publications: |
4 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | down-regulates activity
dephosphorylation
|
ABL1 |
0.399 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277012 |
Tyr226 |
KRNKPTVyGVSPNYD |
Homo sapiens |
|
| pmid |
sentence |
| 28924170 |
We also found that PTPN13 dephosphorylates and inhibits c-Abl.|While the above results indicated that calpain-2 could cleave PTPN13 and that PTPN13 could dephosphorylate c-Abl at tyrosine 245, they did not determine whether calpain-2-mediated cleavage of PTPN13 resulted in its inactivation and increased tyrosine phosphorylation of c-Abl at tyrosine 245. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | up-regulates quantity by stabilization 
dephosphorylation
|
NFKBIA |
0.453 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248712 |
Tyr42 |
DSMKDEEyEQMVKEL |
Homo sapiens |
HEK-293 Cell |
| pmid |
sentence |
| 11106428 |
Identification of IkappaBalpha as a substrate of Fas-associated phosphatase-1|A full-length FAP-1 protein preferentially dephosphorylates Tyr-42 of IkBa|Moreover, other studies have shown that tyrosine phosphorylation of IkBa on Tyr-42 (which occurs with Fas ligand binging) protected against inducible degradation both in vitro [30] and in vivo [38] |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | down-regulates activity
dephosphorylation
|
TRIP6 |
0.444 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248713 |
Tyr55 |
PLPSEQCyQAPGGPE |
Mus musculus |
MEF Cell |
| pmid |
sentence |
| 17591779 |
PTPL1/FAP-1 negatively regulates TRIP6 function in lysophosphatidic acid-induced cell migration.|Here we further demonstrate that a switch from c-Src-mediated phosphorylation to PTPL1/Fas-associated phosphatase-1-dependent dephosphorylation serves as an inhibitory feedback control mechanism of TRIP6 function in LPA-induced cell migration. PTPL1 dephosphorylates phosphotyrosine 55 of TRIP6 in vitro and inhibits LPA-induced tyrosine phosphorylation of TRIP6 in cells. |
|
| Publications: |
1 |
Organism: |
Mus Musculus |
| + |
PTPN13 | down-regulates activity
dephosphorylation
|
IRS1 |
0.48 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277053 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17638892 |
Finally, we report that PTPL1 expression is sufficient to block the IRS-1/phosphatidylinositol 3-kinase/Akt signaling pathway, to inhibit the insulin-like growth factor-I effect on cell survival, and to induce apoptosis.|We first show by complementary approaches that PTPL1 specifically dephosphorylates insulin receptor substrate-1 (IRS-1) in vitro and in cellulo. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | down-regulates activity
dephosphorylation
|
SRC |
0.521 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277125 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19307596 |
Mechanistically, RIL suppresses Src activation through interacting with Src and PTPL1, allowing PTPL1 dependent dephosphorylation of Src at the activation loop.|Our results reveal a novel Src inactivation cycle in which reversion-induced LIM preferentially recognizes active Src and facilitates PTPL1-mediated inactivation of Src. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | up-regulates activity
dephosphorylation
|
EFNB1 |
0.697 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277002 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 23811940 |
Loss of PTPN13 function increases EFNB1 phosphorylation, enhances EFNB1 's interaction with ERBB1 and correlates with potentiated ERK1/2 activation.|Moreover, acquisition of PTPN13 loss-of-function mutations or its decreased expression (due to HPV infection or epigenetic silencing) may further enhance ERBB1 and EFNB1 mediated signals. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | down-regulates activity
dephosphorylation
|
STK25 |
0.431 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248711 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17657516 |
To investigate dephosphorylation of CCM3 by FAP-1, phosphorylated GST-CCM3 was incubated with cdFAP-1, and reactions were analyzed by autoradiography. Again, GST-STK25 phosphorylated GST-CCM3 and possessed autophosphorylation activity. cdFAP-1 of 0.005 U were sufficient to dephosphorylate GST-CCM3 as well as the kinase GST-STK25.|More recently, the Golgi matrix protein GM130 was shown to function as a scaffold protein for STK25 and to activate STK25 through stimulation of autophosphorylation. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | down-regulates activity
dephosphorylation
|
ERBB2 |
0.339 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-277087 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 19734941 |
Since a previous report showed PTPN13 may dephosphorylate ErbB2 directly, we also examined levels of phospho-ErbB2 (tyr 1248), and we also observed a small effect in the presence of wild-type PTPN13 (XREF_FIG).|The fact that both ErbB2 and H-RasV12 were potentiated by PTPN13 loss and PTPN13 inhibited MAP kinase signaling downstream of multiple oncogenes (ErbB2, EGFR, H-RasV12), suggest that the phosphatase target that inhibits MAP kinase signaling may not only be limited to ErbB2 tyrosine 1248. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | down-regulates activity
dephosphorylation
|
PDCD10 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-248714 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17657516 |
In addition, our yeast two-hybrid analysis revealed that CCM3 also binds to the 270-kDa nonreceptor protein tyrosine phos- phatase FAP-1 in a region predicted to contain the C- terminal phosphatase domain [23]. We have shown that this catalytic domain is capable to dephosphorylate CCM3. By dephosphorylation, FAP-1 might therefore negatively reg- ulate CCM3 activity and downstream signaling. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
PTPN13 | down-regulates
dephosphorylation
|
PDCD10 |
0.586 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-157076 |
|
|
Homo sapiens |
|
| pmid |
sentence |
| 17657516 |
We also show that ccm3 directly binds to serine/threonine kinase 25 (stk25, ysk1, sok1) and the phosphatase domain of fas-associated phosphatase-1 (fap-1, ptpn13, ptp-bas, ptp-bl). |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
PTPN13
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