3.0
Summary
| Name |  SLAView Modifications |
| Full Name | Src-like-adapter |
| Synonyms | Src-like-adapter protein 1, SLAP-1, hSLAP | SLAP, SLAP1 |
| Primary ID | Q13239 |
| Links |  -  -  |
| Type | protein |
| Relations | 5 |
| Function | Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. Involved in the negative regulation of positive selection and mitosis of T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | KIT | down-regulates activity 
phosphorylation
|
SLA | 0.2 |
| Publications: | 3 | Organism: | Chlorocebus Aethiops | |
| + | SLA | down-regulates quantity by destabilization
binding
|
EPHA2 | 0.425 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | SLA | down-regulates quantity by destabilization
ubiquitination
|
KIT | 0.2 |
| Publications: | 1 | Organism: | Chlorocebus Aethiops | |