Relation Results

Summary

Name XRCC4
Full Name DNA repair protein XRCC4
Synonyms X-ray repair cross-complementing protein 4 |
Primary ID Q13426
Links - -
Type protein
Relations 7
Function Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. Binds to DNA and to DNA ligase IV ( ...
View More

Viewer

Type: Score: Layout: SPV 
0.3020.9080.9520.70.8220.2SCF-FBW7XRCC4PRKDCLig4-Xrcc4 complexDNA_repairDNA-PKCHD2

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ SCF-FBW7up-regulates activity img/direct-activation.png ubiquitination XRCC4 0.302
Identifier Residue Sequence Organism Cell Line
SIGNOR-277200 Lys296 QENQLQEkENSRPDS Homo sapiens MiaPaCa-2 Cell
pmid sentence
In response to ionizing radiation, ATM phosphorylates FBXW7 at serine 26 to recruit it to DNA double-strand break (DSB) sites, whereas activated DNA-PKcs phosphorylates XRCC4 at serines 325/326, which promotes binding of XRCC4 to FBXW7. SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair. 
Publications: 1 Organism: Homo Sapiens
+ PRKDCup-regulates activity img/direct-activation.png phosphorylation XRCC4 0.908
Identifier Residue Sequence Organism Cell Line
SIGNOR-277198 Ser327 SLETLRNsSPEDLFD Homo sapiens MiaPaCa-2 Cell
pmid sentence
In response to ionizing radiation, ATM phosphorylates FBXW7 at serine 26 to recruit it to DNA double-strand break (DSB) sites, whereas activated DNA-PKcs phosphorylates XRCC4 at serines 325/326, which promotes binding of XRCC4 to FBXW7. SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair. 
Identifier Residue Sequence Organism Cell Line
SIGNOR-277199 Ser328 LETLRNSsPEDLFDE Homo sapiens MiaPaCa-2 Cell
pmid sentence
In response to ionizing radiation, ATM phosphorylates FBXW7 at serine 26 to recruit it to DNA double-strand break (DSB) sites, whereas activated DNA-PKcs phosphorylates XRCC4 at serines 325/326, which promotes binding of XRCC4 to FBXW7. SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair. 
Publications: 2 Organism: Homo Sapiens
+ XRCC4form complex img/form-complex.png binding Lig4-Xrcc4 complex 0.952
Identifier Residue Sequence Organism Cell Line
SIGNOR-264532 in vitro
pmid sentence
The DNA ligase IV-Xrcc4 complex is responsible for the ligation of broken DNA ends in the non-homologous end-joining (NHEJ) pathway of DNA double strand break repair in mammals.
Publications: 1 Organism: In Vitro
+ XRCC4up-regulates img/indirect-activation.png DNA_repair 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264530 Homo sapiens
pmid sentence
The DNA-dependent protein kinase (DNA-PK), consisting of Ku and the DNA-PK catalytic subunit (DNA-PKcs), and the DNA ligase IV-XRCC4 complex function together in the repair of DNA double-strand breaks by non-homologous end joining.
Publications: 1 Organism: Homo Sapiens
+ XRCC4up-regulates activity img/direct-activation.png binding DNA-PK 0.822
Identifier Residue Sequence Organism Cell Line
SIGNOR-277201 Homo sapiens MiaPaCa-2 Cell
pmid sentence
In response to ionizing radiation, ATM phosphorylates FBXW7 at serine 26 to recruit it to DNA double-strand break (DSB) sites, whereas activated DNA-PKcs phosphorylates XRCC4 at serines 325/326, which promotes binding of XRCC4 to FBXW7. SCF(FBXW7) E3 ligase then promotes polyubiquitylation of XRCC4 at lysine 296 via lysine 63 linkage for enhanced association with the Ku70/80 complex to facilitate NHEJ repair. 
Publications: 1 Organism: Homo Sapiens
+ CHD2up-regulates quantity img/direct-activation.png relocalization XRCC4 0.2
Identifier Residue Sequence Organism Cell Line
SIGNOR-264528 Homo sapiens U2-OS Cell
pmid sentence
CHD2 Promotes the Recruitment of Core NHEJ Factors. overexpression of ATPase-dead CHD2 (K515R; Figure S5F), but not wild-type CHD2, also reduced the recruitment of XRCC4 (Figure 5E). Together, these findings suggest that the chromatin remodeling activity of CHD2 promotes the efficient assembly of NHEJ complexes at DSBs.
Publications: 1 Organism: Homo Sapiens
a simple tooltip