Summary

Name NAE1
Full Name NEDD8-activating enzyme E1 regulatory subunit
Synonyms Amyloid beta precursor protein-binding protein 1, 59 kDa, APP-BP1, Amyloid protein-binding protein 1, Proto-oncogene protein 1 | APPBP1
Primary ID Q13564
Links - -
Type protein
Relations 3
Pathways Alzheimer Disease
Function Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. Necessary for cell cycle progression through the S-M checkpoint. Overexpression of NAE1 causes apoptosis through deregulation of NEDD8 conjugation.

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Relations

Regulator Mechanism target score
+ form complex img/form-complex.png binding NAE
Publications: 1 Organism: Homo Sapiens
+ up-regulates activity img/direct-activation.png binding NAE1
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease
+ up-regulates img/indirect-activation.png unknown Apoptosis
Publications: 1 Organism: Homo Sapiens
Pathways:Alzheimer Disease