Relation Results

Summary

Name GRB7
Full Name Growth factor receptor-bound protein 7
Synonyms B47, Epidermal growth factor receptor GRB-7, GRB7 adapter protein
Primary ID Q14451
Links - -
Type protein
Relations 6
Function Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of do ...
View More

Viewer

Type: Score: Layout: SPV 
0.2640.6050.4410.5590.4240.573MAPK8GRB7RND1PTPN11RETINSRKIT

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ MAPK8down-regulates quantity by destabilization img/direct_inhibition.png phosphorylation GRB7 0.264
Identifier Residue Sequence Organism Cell Line
SIGNOR-277280 Ser194 KYELFKSsPHSLFPE Homo sapiens A-431 Cell
pmid sentence
Our data show that phosphorylation of Grb7 protein on the Ser194-Pro motif by c-Jun N-terminal kinase facilitates its binding with the WW domain of Pin1. Subsequently, Grb7 is degraded by the ubiquitin- and proteasome-dependent proteolytic pathway. I
Publications: 1 Organism: Homo Sapiens
+ GRB7up-regulates img/direct-activation.png binding RND1 0.605
Identifier Residue Sequence Organism Cell Line
SIGNOR-74914 Homo sapiens Breast Cancer Cell
pmid sentence
We would like to propose that when cells are driven to divide by growth factor stimulation, grb7 relocalizes at the membrane, in the same subcellular compartment as rnd1, where they could interact in vivo.
Publications: 1 Organism: Homo Sapiens
+ PTPN11up-regulates activity img/direct-activation.png dephosphorylation GRB7 0.441
Identifier Residue Sequence Organism Cell Line
SIGNOR-277169 Homo sapiens
pmid sentence
Dephosphorylation of Grb7 was blocked by the SHP inhibitor NSC-87877 (Zhan et al., 2009), supporting the specificity of SHP-2 in dephosphorylating Grb7.|Nuclear SHP-2 mediates the formation of an EGF induced complex of Grb7, HuR, and CRM1.|Using the \u03ba\u2013opioid receptor (OR [KOR]) as a model, we demonstrate that EGF activates nuclear SHP-2 (Src homology region 2\u2013containing tyrosine phosphatase), which dephosphorylates Grb7 in the nucleus.
Publications: 1 Organism: Homo Sapiens
+ RETup-regulates img/direct-activation.png binding GRB7 0.559
Identifier Residue Sequence Organism Cell Line
SIGNOR-41765 Homo sapiens
pmid sentence
Grb7 and grb10, likely relay signals emanating from ret to other, as yet, unidentified targets within the cell
Publications: 1 Organism: Homo Sapiens
+ INSRup-regulates img/direct-activation.png binding GRB7 0.424
Identifier Residue Sequence Organism Cell Line
SIGNOR-77153 Homo sapiens
pmid sentence
Insulin induces the ir-grb7 interaction in cells expressing physiological levels of the proteins, suggesting that grb7 is implicated in insulin signaling.
Publications: 1 Organism: Homo Sapiens
+ KITup-regulates activity img/direct-activation.png binding GRB7 0.573
Identifier Residue Sequence Organism Cell Line
SIGNOR-248291 Homo sapiens HeLa Cell
pmid sentence
We furthermore demonstrate that the adapter protein Grb2 is a specific binding partner for both phosphorylated Tyr-703 and phosphorylated Tyr-936, whereas the adapter protein Grb7 binds selectively to phosphorylated Tyr-936.
Publications: 1 Organism: Homo Sapiens
a simple tooltip