Relation Results

Summary

Name GRM4
Full Name Metabotropic glutamate receptor 4
Synonyms mGluR4 | GPRC1D, MGLUR4
Primary ID Q14833
Links - -
Type protein
Relations 4
Function G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins ...
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Type: Score: Layout: SPV 
0.80.3340.70.8glutamic acidGRM4GNASExcitatory_synaptic_transmissioncalcium(2+)

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Relations
Regulator
Mechanism
target
score ℹ
+ glutamic acidup-regulates activity img/direct-activation.png chemical activation GRM4 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264074 Homo sapiens
pmid sentence
Metabotropic glutamate receptors are class C G-protein-coupled receptors which respond to the neurotransmitter glutamate
Publications: 1 Organism: Homo Sapiens
+ GRM4up-regulates activity img/direct-activation.png binding GNAS 0.334
Identifier Residue Sequence Organism Cell Line
SIGNOR-264082 Homo sapiens
pmid sentence
MGluRs are members of the G-protein-coupled receptor (GPCR) superfamily, the most abundant receptor gene family in the human genome. GPCRs are membrane-bound proteins that are activated by extracellular ligands such as light, peptides, and neurotransmitters, and transduce intracellular signals via interactions with G proteins. The resulting change in conformation of the GPCR induced by ligand binding activates the G protein, which is composed of a heterotrimeric complex of α, β, and γ subunits.
Publications: 1 Organism: Homo Sapiens
Tissue: Central Nervous System
+ GRM4up-regulates img/indirect-activation.png Excitatory_synaptic_transmission 0.7
Identifier Residue Sequence Organism Cell Line
SIGNOR-264352 Homo sapiens Neuron
pmid sentence
Excitatory synaptic transmission in the mammalian brain is mediated primarily by the amino acid glutamate, activating two different groups of glutamate receptors: ionotropic and metabotropic.
Publications: 1 Organism: Homo Sapiens
+ GRM4up-regulates quantity img/direct-activation.png relocalization calcium(2+) 0.8
Identifier Residue Sequence Organism Cell Line
SIGNOR-264935 Homo sapiens
pmid sentence
Ca2+ is arguably the most important second messenger in the brain because of its pivotal roles in presynaptic neurotransmitter release, postsynaptic responses, and plasticity induction. iGluRs and mGluRs can generate intracellular Ca2+ signals, albeit by different mechanisms, whose crosstalk has not been thoroughly explored (Figure 2C). iGluRs allow the influx of extracellular Ca2+ upon pore opening.
Publications: 1 Organism: Homo Sapiens
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