Summary

Name CUL7
Full Name Cullin-7
Synonyms CUL-7 | KIAA0076
Primary ID Q14999
Links - -
Type protein
Relations 2
Function Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer (PubMed:24793695). Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5 (PubMed:24793696). Core component of a Cul7-RING ubiquitin-protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as GORASP1, IRS1 and MAP4K1/HPK1 (PubMed:21572988, PubMed:24362026). Ubiquitination of GORASP1 regulates Golgi morphogenesis and dendrite patterning in brain (PubMed:21572988). Mediates ubiquitination and degradation of IRS1 in a mTOR-dependent manner

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png neddylation CUL7 0.464
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding Cullin 7-RBX1-Skp1 0.716
Publications: 1 Organism: Homo Sapiens