Summary

Name RBBP5
Full Name Retinoblastoma-binding protein 5
Synonyms RBBP-5, Retinoblastoma-binding protein RBQ-3 | RBQ3
Primary ID Q15291
Links - -
Type protein
Relations 1
Function In embryonic stem (ES) cells, plays a crucial role in the differentiation potential, particularly along the neural lineage, regulating gene induction and H3 'Lys-4' methylation at key developmental loci, including that mediated by retinoic acid (By similarity). Does not affect ES cell self-renewal (By similarity). Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters (PubMed:19131338). As part of the MLL1/MLL complex, involved in mono-, di- and trimethylation at 'Lys-4' of histone H3 (PubMed:19556245). Histone H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation (PubMed:19556245). In association with ASH2L and WDR5, stimulates the histone methyltransferase activities of KMT2A, KMT2B, KMT2C, KMT2D, SETD1A and SETD1B (PubMed:22266653, PubMed:21220120).

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Relations

Regulator Mechanism target score ℹ
+ RBBP5form complex img/form-complex.png binding MLL/SET subcomplex 0.902
Publications: 1 Organism: Homo Sapiens