Summary

Name ZIC1
Full Name Zinc finger protein ZIC 1
Synonyms Zinc finger protein 201, Zinc finger protein of the cerebellum 1 | ZIC, ZNF201
Primary ID Q15915
Links - -
Type protein
Relations 4
Function Acts as a transcriptional activator. Involved in neurogenesis. Plays important roles in the early stage of organogenesis of the CNS, as well as during dorsal spinal cord development and maturation of the cerebellum. Involved in the spatial distribution of mossy fiber (MF) neurons within the pontine gray nucleus (PGN). Plays a role in the regulation of MF axon pathway choice. Promotes MF migration towards ipsilaterally-located cerebellar territories. May have a role in shear flow mechanotransduction in osteocytes. Retains nuclear GLI1 and GLI3 in the cytoplasm. Binds to the minimal GLI-consensus sequence 5'-TGGGTGGTC-3' (By similarity).

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Relations

Regulator Mechanism target score ℹ
+ ZIC1up-regulates img/direct-activation.png relocalization GLI1 0.386
Publications: 1 Organism: Homo Sapiens
+ ZIC1up-regulates img/direct-activation.png relocalization GLI3 0.365
Publications: 1 Organism: Homo Sapiens
+ ZIC1up-regulates img/indirect-activation.png GLI1 0.386
Publications: 1 Organism: Homo Sapiens
+ ZIC1up-regulates img/indirect-activation.png GLI3 0.365
Publications: 1 Organism: Homo Sapiens