3.0
Summary
| Name |  RBBP7View Modifications |
| Full Name | Histone-binding protein RBBP7 |
| Synonyms | Histone acetyltransferase type B subunit 2, Nucleosome-remodeling factor subunit RBAP46, Retinoblastoma-binding protein 7, RBBP-7, Retinoblastoma-binding protein p46 | RBAP46 |
| Primary ID | Q16576 |
| Links |  -  -  |
| Type | protein |
| Relations | 7 |
| Function | Core histone-binding subunit that may target chromatin remodeling factors, histone acetyltransferases and histone deacetylases to their histone substrates in a manner that is regulated by nucleosomal DNA. Component of several complexes which regulate chromatin metabolism. These include the type B histone acetyltransferase (HAT) complex, which is required for chromatin assembly following DNA replication; the core histone deacetylase (HDAC) complex, which promotes histone deacetylation and consequent transcriptional repression; the nucleosome remodeling and histone deacetylase complex (the NuRD complex), which promotes transcriptional repression by histone deacetylation and nucleosome remodeling; and the PRC2/EED-EZH2 complex, which promotes repression of homeotic genes during development; and the NURF (nucleosome remodeling factor) complex. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | AMPK | up-regulates activity 
phosphorylation
|
RBBP7 | 0.26 |
| Publications: | 1 | Organism: | In Vitro | |
| + | PRKAA1 | up-regulates activity
phosphorylation
|
RBBP7 | 0.2 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RBBP7 | up-regulates activity
binding
|
HAT1 | 0.891 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RBBP7 | form complex 
binding
|
MBD2/NuRD complex | 0.824 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBBP7 | form complex
binding
|
MBD3/NuRD complex | 0.828 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | RBBP7 | down-regulates activity 
binding
|
DNMT1 | 0.548 |
| Publications: | 1 | Organism: | In Vitro | |
| + | RBBP7 | form complex
binding
|
HNuRF | 0.558 |
| Publications: | 1 | Organism: | Homo Sapiens | |