Relation Results

Summary

Name RALGAPA2
Full Name Ral GTPase-activating protein subunit alpha-2
Synonyms 250 kDa substrate of Akt, AS250, p220 | C20orf74, KIAA1272
Primary ID Q2PPJ7
Links - -
Type protein
Relations 4
Function Catalytic subunit of the heterodimeric RalGAP2 complex which acts as a GTPase activator for the Ras-like small GTPases RALA and RALB.

Viewer

Type: Score: Layout: SPV 
0.450.603AKT2RALGAPA2RalGAP2

Search Tools

Refine search:

  • by mechanism


  • by effect
  • by organism:


  • by tissue:


  • by cell-line

▶Modifications Tables

Relations
Regulator
Mechanism
target
score ℹ
+ AKT2down-regulates activity img/direct_inhibition.png phosphorylation RALGAPA2 0.45
Identifier Residue Sequence Organism Cell Line
SIGNOR-269797 Ser486 SSWGRTYsFTSAMSR Mus musculus
pmid sentence
RGC2 is an endogenous substrate for Akt2 downstream of PI 3-kinase. kt2 directly phosphorylated all three sites on RGC2 (Figure 5A).
Identifier Residue Sequence Organism Cell Line
SIGNOR-269798 Ser696 TTVGRSFsLSWRSHP Mus musculus
pmid sentence
RGC2 is an endogenous substrate for Akt2 downstream of PI 3-kinase
Identifier Residue Sequence Organism Cell Line
SIGNOR-269799 Thr715 PMRFRSAtTSGAPGV Mus musculus
pmid sentence
RGC2 is an endogenous substrate for Akt2 downstream of PI 3-kinase
Publications: 3 Organism: Mus Musculus
+ RALGAPA2form complex img/form-complex.png binding RalGAP2 0.603
Identifier Residue Sequence Organism Cell Line
SIGNOR-269793 Mus musculus
pmid sentence
Here we report the identification and characterization of a Ral GAP complex (RGC) that mediates the activation of RalA downstream of the PI 3-kinase/Akt pathway. The complex is composed of an RGC1 regulatory subunit and an RGC2 catalytic subunit (previously identified as AS250) that directly stimulates the guanosine triphosphate hydrolysis of RalA.
Publications: 1 Organism: Mus Musculus
a simple tooltip