Relation Results

Name	RNF212
Full Name	Probable E3 SUMO-protein ligase RNF212
Synonyms	Probable E3 SUMO-protein transferase RNF212, RING finger protein 212 \|
Primary ID	Q495C1
Links	- -
Type	protein
Relations	1
Function	SUMO E3 ligase that acts as a regulator of crossing-over during meiosis: required to couple chromosome synapsis to the formation of crossover-specific recombination complexes. Localizes to recombination sites and stabilizes meiosis-specific recombination factors, such as MutS-gamma complex proteins (MSH4 and MSH5) and TEX11. May mediate sumoylation of target proteins MSH4 and/or MSH5, leading to enhance their binding to recombination sites. Acts as a limiting factor for crossover designation and/or reinforcement and plays an antagonist role with CCNB1IP1/HEI10 in the regulation of meiotic recombination (By similarity).