| Name
|
 RIC1
|
| Full Name |
Guanine nucleotide exchange factor subunit RIC1 |
| Synonyms |
Connexin-43-interacting protein of 150 kDa, Protein RIC1 homolog, RAB6A-GEF complex partner protein 1 | CIP150, KIAA1432 |
| Primary ID |
Q4ADV7 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
1 |
| Function |
The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP, and may thereby be required for efficient fusion of endosome-derived vesicles with the Golgi compartment (PubMed:23091056). The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors (PubMed:23091056). Required for phosphorylation and localization of GJA1 (PubMed:16112082). Is a regulator of procollagen transport and secretion, and is required for correct cartilage morphogenesis and development of the craniofacial skeleton (PubMed:31932796). |
4.0
binding