Relation Results

Summary

Name SH3PXD2A
Full Name SH3 and PX domain-containing protein 2A
Synonyms Adapter protein TKS5, Five SH3 domain-containing protein, SH3 multiple domains protein 1, Tyrosine kinase substrate with five SH3 domains | FISH, KIAA0418, SH3MD1, TKS5
Primary ID Q5TCZ1
Links - -
Type protein
Relations 2
Function Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix m ...
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Type: Score: Layout: SPV 
0.4160.645SH3PXD2ANOXA1SRC

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Relations
Regulator
Mechanism
target
score ℹ
+ SH3PXD2Aup-regulates activity img/direct-activation.png binding NOXA1 0.416
Identifier Residue Sequence Organism Cell Line
SIGNOR-264708 Homo sapiens HEK-293 Cell
pmid sentence
Tks4 and Tks5 bind NoxA1 through their SH3 domains in a Rac-independent manner|NoxO1 is required for full Nox1 and Nox3 oxidase activity at least partially because of its role in the plasma membrane recruitment of the NoxA1 activator protein|Tks4 and Tks5 support Nox1- and Nox3-dependent ROS generation
Publications: 1 Organism: Homo Sapiens
+ SRCup-regulates activity img/direct-activation.png phosphorylation SH3PXD2A 0.645
Identifier Residue Sequence Organism Cell Line
SIGNOR-264706
pmid sentence
 Recently, we have shown that tyrosine kinase c-Src substrate Tks4 and Tks5 proteins are novel members of the organizer superfamily
Publications: 1
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