4.0
Summary
| Name |  JADE1View Modifications |
| Full Name | Protein Jade-1 |
| Synonyms | Jade family PHD finger protein 1, PHD finger protein 17 | KIAA1807, PHF17 |
| Primary ID | Q6IE81 |
| Links |  -  -  |
| Type | protein |
| Relations | 4 |
| Function | Scaffold subunit of some HBO1 complexes, which have a histone H4 acetyltransferase activity (PubMed:16387653, PubMed:19187766, PubMed:20129055, PubMed:24065767). Plays a key role in HBO1 complex by directing KAT7/HBO1 specificity towards histone H4 acetylation (H4K5ac, H4K8ac and H4K12ac), regulating DNA replication initiation, regulating DNA replication initiation (PubMed:20129055, PubMed:24065767). May also promote acetylation of nucleosomal histone H4 by KAT5 (PubMed:15502158). Promotes apoptosis (PubMed:16046545). May act as a renal tumor suppressor (PubMed:16046545). Negatively regulates canonical Wnt signaling; at least in part, cooperates with NPHP4 in this function (PubMed:22654112). {ECO:0000269|PubMed:15502158, ECO:0000269|PubMed:16046545, ECO:0000269|PubMed:16387653, ECO:0000269|PubMed:19187766, ECO:0000269|PubMed:20129055, ECO:0000269|PubMed:22654112, ECO:0000269|PubMed:24065767}. |
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Modifications Tables
Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | CSNK1A1 | down-regulates activity 
phosphorylation
|
JADE1 | 0.277 |
| Publications: | 2 | Organism: | Homo Sapiens | |
| + | SIAH1 | down-regulates quantity by destabilization
polyubiquitination
|
JADE1 | 0.291 |
| Publications: | 1 | Organism: | Homo Sapiens | |
| + | PKD1 | down-regulates quantity by destabilization
binding
|
JADE1 | 0.328 |
| Publications: | 1 | Organism: | Homo Sapiens | |