Summary

Name GDF6
Full Name Growth/differentiation factor 6
Synonyms GDF-6, Bone morphogenetic protein 13, BMP-13, Growth/differentiation factor 16 | BMP13, GDF16
Primary ID Q6KF10
Links - -
Type protein
Relations 3
Function Growth factor that controls proliferation and cellular differentiation in the retina and bone formation. Plays a key role in regulating apoptosis during retinal development. Establishes dorsal-ventral positional information in the retina and controls the formation of the retinotectal map (PubMed:23307924). Required for normal formation of bones and joints in the limbs, skull, digits and axial skeleton. Plays a key role in establishing boundaries between skeletal elements during development. Regulation of GDF6 expression seems to be a mechanism for evolving species-specific changes in skeletal structures. Seems to positively regulate differentiation of chondrogenic tissue through the growth factor receptors subunits BMPR1A, BMPR1B, BMPR2 and ACVR2A, leading to the activation of SMAD1-SMAD5-SMAD8 complex. The regulation of chondrogenic differentiation is inhibited by NOG (PubMed:26643732). Also involved in the induction of adipogenesis from mesenchymal stem cells. This mechanism acts through the growth factor receptors subunits BMPR1A, BMPR2 and ACVR2A and the activation of SMAD1-SMAD5-SMAD8 complex and MAPK14/p38 (By similarity).

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Relations

Regulator Mechanism target score
+ up-regulates img/direct-activation.png binding BMPR1A 0.589
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR1A/1B/2 0.594
Publications: 1 Organism: Homo Sapiens
+ up-regulates img/direct-activation.png binding BMPR2 0.585
Publications: 1 Organism: Homo Sapiens