Summary

Name SLC30A10
Full Name Zinc transporter 10
Synonyms ZnT-10, Solute carrier family 30 member 10 | ZNT10, ZNT8
Primary ID Q6XR72
Links - -
Type protein
Relations 3
Function Plays a pivotal role in manganese transport. Manganese is an essential cation for the function of several enzymes, including some crucially important for the metabolism of neurotransmitters and other neuronal metabolic pathways. However, elevated levels of manganese are cytotoxic and induce oxidative stress, mitochondrial dysfunction and apoptosis. Acts as manganese efflux transporter and confers protection against manganese-induced cell death (PubMed:22341972, PubMed:22341971, PubMed:25319704, PubMed:27226609, PubMed:27307044). Also acts as zinc transporter involved in zinc homeostasis. Seems to mediate zinc transport into early endosomes and recycling endosomes to prevent zinc toxicity; the function may be regulated by heterodimerization with other zinc transporters of the SLC30A subfamily. The SLC30A3:SLC30A10 heterodimer is involved in zinc transport-dependent regulation of the EGFR/ERK transduction pathway in endosomes. May be involved in regulation of zinc-dependent senescence of vascular smooth muscle cells (PubMed:22706290, PubMed:22427991, PubMed:26728129).

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Relations

Regulator Mechanism target score ℹ
+ SLC30A10form complex img/form-complex.png binding ZNT3-ZNT10 proton-coupled zinc antiporter complex 0.418
Publications: 1 Organism: Homo Sapiens
+ SLC30A10form complex img/form-complex.png binding ZNT4-ZNT10 proton-coupled zinc antiporter complex 0.407
Publications: 1 Organism: Homo Sapiens
+ SLC30A10form complex img/form-complex.png binding ZNT2-ZNT10 proton-coupled zinc antiporter complex 0.413
Publications: 1 Organism: Homo Sapiens