+ |
CSNK2A2 | up-regulates activity
phosphorylation
|
UBE2R2 |
0.461 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-251047 |
Ser233 |
DCYDDDDsGNEES |
Homo sapiens |
|
pmid |
sentence |
12037680 |
UBC3B is specifically phosphorylated by CK2 in vitro and in vivo. We mapped by deletions and site directed mutagenesis the phosphorylation site to a serine residue within the C-terminal domain in position 233 of UBC3B and in the corresponding serine residue of UBC3. | Following CK2-dependent phosphorylation both UBC3B and UBC3 bind to the F-box protein beta-TrCP, the substrate recognition subunit of an SCF (Skp1, Cul1, F-box) ubiquitin ligase. Furthermore, we observed that co-transfection of CK2alpha' together with UBC3B, but not with UBC3DeltaC, enhances the degradation of beta-catenin. |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
CSNK2A1 | up-regulates activity
phosphorylation
|
UBE2R2 |
0.344 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-88050 |
Ser233 |
DCYDDDDsGNEES |
Homo sapiens |
|
pmid |
sentence |
12037680 |
Ck2-dependent phosphorylation of the e2 ubiquitin conjugating enzyme ubc3b induces its interaction with beta-trcp and enhances beta-catenin degradation |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
Ub:E1 (UBA6 substrate) | up-regulates activity
ubiquitination
|
UBE2R2 |
0.776 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271358 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |
+ |
Ub:E1 (UBA1 substrate) | up-regulates activity
ubiquitination
|
UBE2R2 |
0.755 |
Identifier |
Residue |
Sequence |
Organism |
Cell Line |
SIGNOR-271324 |
|
|
Homo sapiens |
|
pmid |
sentence |
34199813 |
The ubiquitination process is mediated sequentially by three classes of enzymes consisting of a Ub-activating enzyme E1, a Ub-conjugating enzyme E2, and a Ub ligase E3. Ub is first activated by E1 in an adenosine 5′-triphosphate (ATP)-dependent manner t |
|
Publications: |
1 |
Organism: |
Homo Sapiens |