Summary

Name MED13L
Full Name Mediator of RNA polymerase II transcription subunit 13-like
Synonyms Mediator complex subunit 13-like, Thyroid hormone receptor-associated protein 2, Thyroid hormone receptor-associated protein complex 240 kDa component-like | KIAA1025, PROSIT240, THRAP2, TRAP240L
Primary ID Q71F56
Links - -
Type protein
Relations 3
Function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. This subunit may specifically regulate transcription of targets of the Wnt signaling pathway and SHH signaling pathway.

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MED13L 0.366
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png ubiquitination MED13L 0.366
Publications: 1 Organism: Homo Sapiens
+ form complex img/form-complex.png binding CKM complex 0.761
Publications: 1 Organism: Homo Sapiens