| + |
EMSY | up-regulates activity 
binding
|
ZMYND11 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263916 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 14651845 |
The binding sites for HP1β and BS69 with EMSY abut each other, and are found directly adjacent to the ENT domain of EMSY. This demonstrates that EMSY has the capacity to contact directly at least two proteins which contain a Royal Family domain. Since this domain is found in proteins with a chromatin connection, we assume that EMSY functions, at least partly, in the regulation of chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EMSY | up-regulates activity
binding
|
CBX1 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263917 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 14651845 |
The binding sites for HP1β and BS69 with EMSY abut each other, and are found directly adjacent to the ENT domain of EMSY. This demonstrates that EMSY has the capacity to contact directly at least two proteins which contain a Royal Family domain. Since this domain is found in proteins with a chromatin connection, we assume that EMSY functions, at least partly, in the regulation of chromatin. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
| + |
EMSY | down-regulates activity 
binding
|
BRCA2 |
0.2 |
| Identifier |
Residue |
Sequence |
Organism |
Cell Line |
| SIGNOR-263915 |
|
|
Homo sapiens |
HeLa Cell |
| pmid |
sentence |
| 14651845 |
The EMSY protein interacts precisely with a highly conserved transactivating region at the N terminus of the breast cancer protein BRCA2, and has endogenous transcriptional repressor activity when recruited to a high basal promoter. We have suggested that the independent activation domain of BRCA2 within exon 3 might have some role in transcription (Milner et al., 1997). The identification of the repressor protein EMSY, which binds and silences this domain, is consistent with such a function. |
|
| Publications: |
1 |
Organism: |
Homo Sapiens |
3.0
EMSY
- 
- 