Relation Results

Summary

Name LDB1
Full Name LIM domain-binding protein 1
Synonyms LDB-1, Carboxyl-terminal LIM domain-binding protein 2, CLIM-2, LIM domain-binding factor CLIM2, hLdb1, Nuclear LIM interactor | CLIM2
Primary ID Q86U70
Links - -
Type protein
Relations 2
Function Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing ...
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Type: Score: Layout: SPV 
0.5420.57LDB1LHX2RLIM

Relations

Regulator
Mechanism
target
score
+ up-regulates activity img/direct-activation.png binding LHX2 0.542
Identifier Residue Sequence Organism Cell Line
SIGNOR-223962 Homo sapiens HEK-293 Cell
pmid sentence
Cofactor CLIM2 promotes the repressive action of LIM homeodomain transcription factor Lhx2 in the expression of porcine pituitary glycoprotein hormone alpha subunit gene.
Publications: 1 Organism: Homo Sapiens
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination LDB1 0.57
Identifier Residue Sequence Organism Cell Line
SIGNOR-272617 Cricetulus griseus CHO Cell
pmid sentence
Here we identify RLIM as a ubiquitin protein ligase that is able to target CLIM cofactors for degradation through the 26S proteasome pathway. 
Publications: 1 Organism: Cricetulus Griseus
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