Summary

Name LDB1
Full Name LIM domain-binding protein 1
Synonyms LDB-1, Carboxyl-terminal LIM domain-binding protein 2, CLIM-2, LIM domain-binding factor CLIM2, hLdb1, Nuclear LIM interactor | CLIM2
Primary ID Q86U70
Links - -
Type protein
Relations 2
Function Binds to the LIM domain of a wide variety of LIM domain-containing transcription factors. May regulate the transcriptional activity of LIM-containing proteins by determining specific partner interactions. Plays a role in the development of interneurons and motor neurons in cooperation with LHX3 and ISL1. Acts synergistically with LHX1/LIM1 in axis formation and activation of gene expression. Acts with LMO2 in the regulation of red blood cell development, maintaining erythroid precursors in an immature state (By similarity).

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Relations

Regulator Mechanism target score
+ down-regulates quantity by destabilization img/direct_inhibition.png polyubiquitination LDB1 0.585
Publications: 1 Organism: Cricetulus Griseus
+ up-regulates activity img/direct-activation.png binding LHX2 0.555
Publications: 1 Organism: Homo Sapiens