4.0
Summary
| Name |  PPARGC1B
|
| Full Name | Peroxisome proliferator-activated receptor gamma coactivator 1-beta |
| Synonyms | PGC-1-beta, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PGC-1-related estrogen receptor alpha coactivator | PERC, PGC1, PGC1B, PPARGC1 |
| Primary ID | Q86YN6 |
| Links |  -  -  |
| Type | protein |
| Relations | 0 |
| Function | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. |