Summary

Name SIAH3
Full Name Seven in absentia homolog 3
Synonyms Siah-3 |
Primary ID Q8IW03
Links - -
Type protein
Relations 1
Function Negative regulator of PRKN translocation to damaged mitochondria. Acts probably by destabilizing PINK1 protein, hence inhibiting PRKN targeting to dysfunctional depolarized mitochondria.

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Relations

Regulator Mechanism target score
+ up-regulates activity img/direct-activation.png ubiquitination SIAH3 0.2
Publications: 1 Organism: Homo Sapiens