| Name
|
 HS3ST5
|
| Full Name |
Heparan sulfate glucosamine 3-O-sulfotransferase 5 |
| Synonyms |
Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5, 3-OST-5, Heparan sulfate 3-O-sulfotransferase 5, h3-OST-5 | 3OST5, HS3OST5 |
| Primary ID |
Q8IZT8 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to position 3 of glucosamine residues in heparan. Catalyzes the rate limiting step in the biosynthesis of heparan sulfate (HSact). This modification is a crucial step in the biosynthesis of anticoagulant heparan sulfate as it completes the structure of the antithrombin pentasaccharide binding site. Also generates GlcUA-GlcNS or IdoUA-GlcNS and IdoUA2S-GlcNH2. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry. |
4.0