Summary

Name ARID1B
Full Name AT-rich interactive domain-containing protein 1B
Synonyms ARID domain-containing protein 1B, BRG1-associated factor 250b, BAF250B, BRG1-binding protein hELD/OSA1, Osa homolog 2, hOsa2, p250R | BAF250B, DAN15, KIAA1235, OSA2
Primary ID Q8NFD5
Links - -
Type protein
Relations 4
Function Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Binds DNA non-specifically (PubMed:14982958, PubMed:15170388).

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Relations

Regulator Mechanism target score ℹ
+ ARID1Bform complex img/form-complex.png binding BAF250b E3 ligase 0.342
Publications: 1 Organism: Homo Sapiens
+ ARID1Bform complex img/form-complex.png binding Muscle cell-specific SWI/SNF ARID1B variant 0.799
Publications: 1 Organism: Homo Sapiens
Tissue: Muscle
+ ARID1Bdown-regulates activity img/direct_inhibition.png ubiquitination Histone H2B 0.2
Publications: 1 Organism: In Vitro
+ ARID1Bform complex img/form-complex.png binding SWI/SNF complex 0.779
Publications: 1 Organism: Homo Sapiens