3.0
Summary
| Name |  GADD45GIP1
|
| Full Name | Growth arrest and DNA damage-inducible proteins-interacting protein 1 |
| Synonyms | 39S ribosomal protein L59, mitochondrial, MRP-L59, CKII beta-associating protein, CR6-interacting factor 1, CRIF1, Mitochondrial large ribosomal subunit protein mL64, Papillomavirus L2-interacting nuclear protein 1, PLINP, PLINP-1, p53-responsive gene 6 protein | MRPL59, PLINP1, PRG6 |
| Primary ID | Q8TAE8 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis. |
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Relations
| Regulator | Mechanism | target | score ℹ | |
|---|---|---|---|---|
| + | GADD45GIP1 | form complex 
binding
|
39S mitochondrial large ribosomal subunit | 0.615 |
| Publications: | 1 | Organism: | In Vitro | |