Summary

Name ACMSD
Full Name 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Synonyms Picolinate carboxylase |
Primary ID Q8TDX5
Links - -
Type protein
Relations 0
Function Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

Viewer