3.0
Summary
| Name |  SH3RF2
|
| Full Name | E3 ubiquitin-protein ligase SH3RF2 |
| Synonyms | Heart protein phosphatase 1-binding protein, HEPP1, POSH-eliminating RING protein, Protein phosphatase 1 regulatory subunit 39, RING finger protein 158, RING-type E3 ubiquitin transferase SH3RF2, SH3 domain-containing RING finger protein 2 | POSH3, POSHER, PPP1R39, RNF158 |
| Primary ID | Q8TEC5 |
| Links |  -  -  |
| Type | protein |
| Relations | 1 |
| Function | Has E3 ubiquitin-protein ligase activity (PubMed:24130170). Acts as an anti-apoptotic regulator of the JNK pathway by ubiquitinating and promoting the degradation of SH3RF1, a scaffold protein that is required for pro-apoptotic JNK activation (PubMed:22128169). Facilitates TNF-alpha-mediated recruitment of adapter proteins TRADD and RIPK1 to TNFRSF1A and regulates PAK4 protein stability via inhibition of its ubiquitin-mediated proteasomal degradation (PubMed:24130170). Inhibits PPP1CA phosphatase activity (PubMed:19945436, PubMed:19389623). |
ubiquitination