4.0
Summary
| Name |  DENND1A
|
| Full Name | DENN domain-containing protein 1A |
| Synonyms | Connecdenn 1, Connecdenn, Protein FAM31A | FAM31A, KIAA1608 |
| Primary ID | Q8TEH3 |
| Links |  -  -  |
| Type | protein |
| Relations | 0 |
| Function | Guanine nucleotide exchange factor (GEF) regulating clathrin-mediated endocytosis through RAB35 activation. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB35 into its active GTP-bound form. Regulates clathrin-mediated endocytosis of synaptic vesicles and mediates exit from early endosomes (PubMed:20154091, PubMed:20937701). Binds phosphatidylinositol-phosphates (PtdInsPs), with some preference for PtdIns(3)P (By similarity). |