| Name
|
 CASTOR1
|
| Full Name |
Cytosolic arginine sensor for mTORC1 subunit 1 |
| Synonyms |
Cellular arginine sensor for mTORC1 protein 1, CASTOR1 | CASTOR1 |
| Primary ID |
Q8WTX7 |
| Links |
 -  -  |
| Type |
protein |
| Relations |
0 |
| Function |
Functions as an intracellular arginine sensor within the amino acid-sensing branch of the TORC1 signaling pathway. As a homodimer or a heterodimer with CASTOR2, binds and inhibits the GATOR subcomplex GATOR2 and thereby mTORC1. Binding of arginine to CASTOR1 allosterically disrupts the interaction of CASTOR1-containing dimers with GATOR2 which can in turn activate mTORC1 and the TORC1 signaling pathway. |
4.0