3.0
Summary
| Name |  KCTD13
|
| Full Name | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1 |
| Synonyms | hBACURD1, BTB/POZ domain-containing protein KCTD13, Polymerase delta-interacting protein 1, TNFAIP1-like protein | BACURD1, PDIP1, POLDIP1 |
| Primary ID | Q8WZ19 |
| Links |  -  -  |
| Type | protein |
| Relations | 2 |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex required for synaptic transmission (PubMed:19782033). The BCR(KCTD13) E3 ubiquitin ligase complex mediates the ubiquitination of RHOA, leading to its degradation by the proteasome (PubMed:19782033) Degradation of RHOA regulates the actin cytoskeleton and promotes synaptic transmission (By similarity). |
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