Summary

Name POMGNT1
Full Name Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1
Synonyms POMGnT1, UDP-GlcNAc:alpha-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I.2, GnT I.2 | MGAT1.2
Primary ID Q8WZA1
Links - -
Type protein
Relations 1
Function Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins (PubMed:11709191, PubMed:27493216, PubMed:28512129). Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties (PubMed:11709191, PubMed:27493216). Is specific for alpha linked terminal mannose and does not have MGAT3, MGAT4, MGAT5, MGAT7 or MGAT8 activity.

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Relations

Regulator Mechanism target score ℹ
+ ZNF202down-regulates quantity by repression img/indirect_inhibition.png transcriptional regulation POMGNT1 0.254
Publications: 1 Organism: Homo Sapiens